If your vehicle has a protective coating on its windshield or electronic devices which interferes with the device receiving a signal, your device may not be able to acquire satellites in this environment.
Some vehicles are equipped with special windshields that may contain metal in the glass (metal oxide) that prevents the GPS device from having a clear line of sight to the satellites.
Windshields with solar ray glass, solar tint, heated, or heat-reflective windshields and insulated or Insta-Clear glass may also affect satellite acquisition.
If you suspect this to be an issue, try taking the device outside of the vehicle with a clear view of the sky for 3-5 minutes so that the device can acquire satellites.
If your device loses satellites once moved back into your vehicle, this is most likely the reason.
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